HLA ADR Technical Information

ALDAS system for Drug Sensitivity Testing
 


Technical Information.

 

The ALDAS HLA ADR Test Kit contains all components required for the PCR reaction and testwells with immobilized sequence-specific oligonucleotide probes for the detection of 23 specific HLA alleles with known associations to adverse drug reactions [1].

HLA-A HLA-B HLA-C HLA-DRB1 HLA-DQA1 HLA-DQB1
A*31:01 B*13:01 C*04:01 DRB1*07:01 DQA1*01:02 DQB1*02:01
A*33:03 B*15:02 C*08:01 DRB1*11:01 DQA1*02:01 DQB1*03:03
A*68:01 B*35:05   DRB1*13:02   DQB1*05:02
  B*56:02   DRB1*15:01   DQB1*06:02
  B*57:01       DQB1*06:04
  B*58:01       DQB1*06:09


The system consists of the ALDAS HLA ADR Test Kit, the ALDAS Reagent Kit, the ALDAS Instrument and the MCD MATCH Interpretation Software.

The ALDAS HLA ADR Test Kit contain all components required for the PCR reaction and testwells with immobilized sequence-specific oligonucleotide probes for the detection of the PCR products. The ALDAS Reagent Kit contains the reagents for the hybridisation and detection and can be used in combination with all ALDAS HLA ADR Test Kits. The ALDAS instrument is specifically designed to be used with the ALDAS HLA ADR to process between 1 and 6 samples, automating the process from hybridisation, detection through to result interpretation. The MCD MATCH Interpretation Software is required to interpret the results.

The ALDAS HLA ADR Test Kit is a combination of all components necessary to identify the 23 alleles. The kit is designed to make the workflow as easy as possible. The amplification primers are pre-dispensed and dried in PCR strips and the SSO tests are combined in a holder. The procedure and the interpretation of this test combination is controlled via the MCD MATCH Interpretation Software.

Instructions for Use-   

HLA-ADR Kits
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MCD MATCH Software
Coming soon

ALDAS Processor
Coming soon

HLA-ADR MSDS Declaration
Coming soon

1. Pirmohamed, M., Ostrov, D. and Park, B. (2015). New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity. Journal of Allergy and Clinical Immunology, 136(2), pp.236-244.

 


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