Ankylosing Spondylitis - Disease Association Testing

07 Jun 2018 0 Comments 0 Trackbacks Jessica Harland

Bechterew’s disease or Ankylosing Spondylitis is a chronic autoimmune disease effecting sacroiliac joints, spine, and peripheral arthritis. The incidence of disease generally occurs during teenage years and is three times more prevalent in males than females (3:1 ratio) (1). Common symptoms of Ankylosing Spondylitis include back pain and joint swelling, stiffness and extreme fatigue.

The HLA-B*27 protein is a variant of the human leukocyte antigen-B (HLA-B) and has a strong association with this autoimmune disease and is therefore, used as part of the diagnostic procedure (2, 3). A positive HLA-B*27 result is associated with a very high disease risk. In suspected cases of Ankylosing Spondylitis, a HLA-B*27 diagnosis provides an important contribution to the therapy of the patient. Around 3% to 6% of the people carrying the HLA-B*27 gene develop Anklylosing Spondylitis and more than 90% of all patients with a seronegative arthritis have this gene.

From April 2018 our new HISTO TYPE B*27 realtime PCR kit for fast and easy detection of HLA-B*27 is available. The HISTO TYPE B*27 Q kit covers all common HLA-B*27 sub types. Moreover, the kit differentiates between the disease associated alleles and the sub types HLA-B*27:06 or HLAB*27:09, which are not associated with Ankylosing spondylitis (4). 

 An easily implementable test compatible with most common realtime cyclers.

Visit our technical page for further information on how this test is applied.  

 

1. Braun, J et al., 1998. Arthritis & Rheumatism, 41(1), 58-67

 

2. Brewerton, DA et al., 1973. Lancet i:904-907

3. Schlosstien L et al., 1973. N. Engl. J. Med. 288:704-706

4. Kahn, MA et al., 2007. Autoimmunity Reviews 6: 183–189

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